View source for 7r80


==Crystal structure of C3 TCR complex with QW9-bound HLA-B*5301==
<StructureSection load='7r80' size='340' side='right'caption='[[7r80]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7r80]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/HIV-1_06TG.HT008 HIV-1 06TG.HT008] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R80 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r80 OCA], [https://pdbe.org/7r80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r80 RCSB], [https://www.ebi.ac.uk/pdbsum/7r80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r80 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/S6BVK3_HUMAN S6BVK3_HUMAN] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Cytotoxic-T-lymphocyte (CTL) mediated control of HIV-1 is enhanced by targeting highly networked epitopes in complex with human-leukocyte-antigen-class-I (HLA-I). However, the extent to which the presenting HLA allele contributes to this process is unknown. Here we examine the CTL response to QW9, a highly networked epitope presented by the disease-protective HLA-B57 and disease-neutral HLA-B53. Despite robust targeting of QW9 in persons expressing either allele, T cell receptor (TCR) cross-recognition of the naturally occurring variant QW9_S3T is consistently reduced when presented by HLA-B53 but not by HLA-B57. Crystal structures show substantial conformational changes from QW9-HLA to QW9_S3T-HLA by both alleles. The TCR-QW9-B53 ternary complex structure manifests how the QW9-B53 can elicit effective CTLs and suggests sterically hindered cross-recognition by QW9_S3T-B53. We observe populations of cross-reactive TCRs for B57, but not B53 and also find greater peptide-HLA stability for B57 in comparison to B53. These data demonstrate differential impacts of HLAs on TCR cross-recognition and antigen presentation of a naturally arising variant, with important implications for vaccine design.

Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide.,Li X, Singh NK, Collins DR, Ng R, Zhang A, Lamothe-Molina PA, Shahinian P, Xu S, Tan K, Piechocka-Trocha A, Urbach JM, Weber JK, Gaiha GD, Takou Mbah OC, Huynh T, Cheever S, Chen J, Birnbaum M, Zhou R, Walker BD, Wang JH Nat Commun. 2023 May 22;14(1):2929. doi: 10.1038/s41467-023-38573-8. PMID:37217466<ref>PMID:37217466</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7r80" style="background-color:#fffaf0;"></div>

==See Also==
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[MHC 3D structures|MHC 3D structures]]
*[[MHC I 3D structures|MHC I 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: HIV-1 06TG HT008]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Li XL]]
[[Category: Tan KM]]
[[Category: Walker BD]]
[[Category: Wang JH]]