View source for 7rsv


==Structure of the VPS34 kinase domain with compound 5==
<StructureSection load='7rsv' size='340' side='right'caption='[[7rsv]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7rsv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RSV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7IQ:(5aS,8aR,9S)-2-[(3R)-3-methylmorpholin-4-yl]-5,5a,6,7,8,8a-hexahydro-4H-cyclopenta[e]pyrazolo[1,5-a]pyrazin-4-one'>7IQ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rsv OCA], [https://pdbe.org/7rsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rsv RCSB], [https://www.ebi.ac.uk/pdbsum/7rsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rsv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref> 

==See Also==
*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chan GKY]]
[[Category: Chen H]]
[[Category: Chen Y]]
[[Category: Dimitrova YN]]
[[Category: Hu DX]]
[[Category: Huang H]]
[[Category: Lee JY]]
[[Category: Lim J]]
[[Category: McNamara E]]
[[Category: Moffat JG]]
[[Category: Murthy A]]
[[Category: Pang J]]
[[Category: Patel S]]
[[Category: Prangley MS]]
[[Category: Salphati L]]
[[Category: Schutt LK]]
[[Category: Siu M]]
[[Category: Sneeringer CJ]]
[[Category: Staben S]]
[[Category: Wallweber HA]]
[[Category: Wang S]]
[[Category: Wang Y]]
[[Category: Wu C]]
[[Category: Zhao W]]