View source for 7rsw


==Crystal structure of group B human rotavirus VP8*==
<StructureSection load='7rsw' size='340' side='right'caption='[[7rsw]], [[Resolution|resolution]] 1.32&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7rsw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_rotavirus_B Human rotavirus B] and [https://en.wikipedia.org/wiki/Rotavirus Rotavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RSW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.32&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rsw OCA], [https://pdbe.org/7rsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rsw RCSB], [https://www.ebi.ac.uk/pdbsum/7rsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rsw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/H0USR8_ROTGA H0USR8_ROTGA] Outer capsid protein VP4: Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. It is subsequently lost, together with VP7, following virus entry into the host cell. Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion. This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.[HAMAP-Rule:MF_04125]
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</StructureSection>
[[Category: Human rotavirus B]]
[[Category: Large Structures]]
[[Category: Rotavirus]]
[[Category: Hu L]]
[[Category: Prasad BV]]
[[Category: Salmen W]]
[[Category: Sankaran B]]