View source for 7rta


==Crystal structures of human PYY and NPY==
<StructureSection load='7rta' size='340' side='right'caption='[[7rta]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7rta]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RTA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RTA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rta OCA], [https://pdbe.org/7rta PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rta RCSB], [https://www.ebi.ac.uk/pdbsum/7rta PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rta ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NPY_HUMAN NPY_HUMAN] NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Neuropeptide Y (NPY), peptide YY (PYY) and pancreatic polypeptide (PP) form the evolutionarily conserved pancreatic polypeptide family. While the fold is widely utilized in nature, crystal structures remain elusive, particularly for the human forms, with only the structure of a distant avian form of PP reported. Here we utilize a crystallization chaperone (antibody Fab fragment), specifically recognizing the amidated peptide termini, to solve the structures of human NPY and human PYY. Intriguingly, and despite limited sequence identity (~50%), the structure of human PYY closely resembles that of avian PP, highlighting the broad structural conservation of the fold throughout evolution. Specifically, the PYY structure is characterized by a C-terminal amidated alpha-helix, preceded by a backfolded poly-proline N-terminus, with the termini in close proximity to each other. In contrast, in the structure of human NPY the N-terminal component is disordered, while the helical component of the peptide is observed in a four-helix bundle type arrangement, consistent with a propensity for multimerization suggested by NMR studies.

Crystal structures of human neuropeptide Y (NPY) and peptide YY (PYY).,Langley DB, Schofield P, Jackson J, Herzog H, Christ D Neuropeptides. 2022 Apr;92:102231. doi: 10.1016/j.npep.2022.102231. Epub 2022 Feb , 7. PMID:35180645<ref>PMID:35180645</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7rta" style="background-color:#fffaf0;"></div>

==See Also==
*[[Antibody 3D structures|Antibody 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Christ D]]
[[Category: Langley DB]]