View source for 7ru6


==Cryo-EM structure of the HIV-1 restriction factor human SERINC3==
<StructureSection load='7ru6' size='340' side='right'caption='[[7ru6]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ru6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RU6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ru6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ru6 OCA], [https://pdbe.org/7ru6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ru6 RCSB], [https://www.ebi.ac.uk/pdbsum/7ru6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ru6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SERC3_HUMAN SERC3_HUMAN] Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).<ref>PMID:26416733</ref> <ref>PMID:26416734</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Leonhardt SA]]
[[Category: Purdy MD]]
[[Category: Yeager M]]