View source for 7ruh


==Bromodomain-containing protein 4 (BRD4) bromodomain 2 (BD2) complexed with XR844==
<StructureSection load='7ruh' size='340' side='right'caption='[[7ruh]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ruh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RUH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7QZ:1-[5-[1-(1,1-dipyridin-2-ylethyl)-4-[2,2,2-tris(fluoranyl)ethylsulfonylamino]indol-6-yl]-1-methyl-2-oxidanylidene-pyridin-3-yl]-3-(2-fluorophenyl)urea'>7QZ</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ruh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ruh OCA], [https://pdbe.org/7ruh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ruh RCSB], [https://www.ebi.ac.uk/pdbsum/7ruh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ruh ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> 
== Function ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

==See Also==
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dubrovyskyii O]]
[[Category: Huang F]]
[[Category: Li Y]]
[[Category: Ratia KM]]
[[Category: Shen Z]]
[[Category: Thatcher GR]]
[[Category: Xiong R]]
[[Category: Zhao J]]