View source for 7rzo


==Crystal structure of a dihydrofolate reductase (folA) from Stenotrophomonas maltophilia==
<StructureSection load='7rzo' size='340' side='right'caption='[[7rzo]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7rzo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Stenotrophomonas_maltophilia_K279a Stenotrophomonas maltophilia K279a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RZO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RZO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rzo OCA], [https://pdbe.org/7rzo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rzo RCSB], [https://www.ebi.ac.uk/pdbsum/7rzo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rzo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/B2FPG1_STRMK B2FPG1_STRMK] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[ARBA:ARBA00025067][PIRNR:PIRNR000194]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Stenotrophomonas maltophilia K279a]]