View source for 7she


==Cryo-EM structure of human GPR158==
<StructureSection load='7she' size='340' side='right'caption='[[7she]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7she]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SHE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=EIJ:(2S)-1-{[(S)-hydroxy{[(1s,2R,3R,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl+(5E,8E,11E,14E)-icosa-5,8,11,14-tetraenoate'>EIJ</scene>, <scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7she FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7she OCA], [https://pdbe.org/7she PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7she RCSB], [https://www.ebi.ac.uk/pdbsum/7she PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7she ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/GP158_HUMAN GP158_HUMAN]] Orphan receptor. 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
[Figure: see text].

Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gbeta5 signaling complex.,Patil DN, Singh S, Laboute T, Strutzenberg TS, Qiu X, Wu D, Novick SJ, Robinson CV, Griffin PR, Hunt JF, Izard T, Singh AK, Martemyanov KA Science. 2021 Nov 18:eabl4732. PMID:34793198<ref>PMID:34793198</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7she" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Martemyanov, K A]]
[[Category: Patil, D N]]
[[Category: Singh, A K]]
[[Category: Singh, S]]
[[Category: Receptor]]
[[Category: Signaling protein]]