View source for 7sip


==Structure of shaker-IR==
<StructureSection load='7sip' size='340' side='right'caption='[[7sip]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SIP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sip OCA], [https://pdbe.org/7sip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sip RCSB], [https://www.ebi.ac.uk/pdbsum/7sip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sip ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Voltage-activated potassium (Kv) channels open upon membrane depolarization and proceed to spontaneously inactivate. Inactivation controls neuronal firing rates and serves as a form of short-term memory and is implicated in various human neurological disorders. Here, we use high-resolution cryo-electron microscopy and computer simulations to determine one of the molecular mechanisms underlying this physiologically crucial process. Structures of the activated Shaker Kv channel and of its W434F mutant in lipid bilayers demonstrate that C-type inactivation entails the dilation of the ion selectivity filter and the repositioning of neighboring residues known to be functionally critical. Microsecond-scale molecular dynamics trajectories confirm that these changes inhibit rapid ion permeation through the channel. This long-sought breakthrough establishes how eukaryotic K(+) channels self-regulate their functional state through the plasticity of their selectivity filters.

Structure of the Shaker Kv channel and mechanism of slow C-type inactivation.,Tan XF, Bae C, Stix R, Fernandez-Marino AI, Huffer K, Chang TH, Jiang J, Faraldo-Gomez JD, Swartz KJ Sci Adv. 2022 Mar 18;8(11):eabm7814. doi: 10.1126/sciadv.abm7814. Epub 2022 Mar, 18. PMID:35302848<ref>PMID:35302848</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7sip" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Bae C]]
[[Category: Chang T]]
[[Category: Faraldo-Gomez JD]]
[[Category: Fernandez AI]]
[[Category: Huffer K]]
[[Category: Jiang J]]
[[Category: Stix R]]
[[Category: Swartz KJ]]
[[Category: Tan X]]