View source for 7smh


==Structure of SASG A-domain (residues 163-419) from Staphylococcus aureus==
<StructureSection load='7smh' size='340' side='right'caption='[[7smh]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7smh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_NCTC_8325 Staphylococcus aureus subsp. aureus NCTC 8325]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SMH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7smh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7smh OCA], [https://pdbe.org/7smh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7smh RCSB], [https://www.ebi.ac.uk/pdbsum/7smh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7smh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SASG_STAA8 SASG_STAA8] Promotes adhesion of bacterial cells to human squamous nasal epithelial cells, a phenomenon which is likely to be important in nasal colonization. Forms short, extremely dense and thin fibrils all over the bacterial surface. Does not bind to either buccal cells or non-differentiated keratinocytes. Promotes cellular aggregation leading to biofilm formation.<ref>PMID:14523109</ref> <ref>PMID:17660408</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus subsp. aureus NCTC 8325]]
[[Category: Atkin KE]]
[[Category: Brentnall AS]]
[[Category: Dodson EJ]]
[[Category: Potts JR]]
[[Category: Turkenburg JP]]
[[Category: Whelan F]]