View source for 7stg


==Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity==
<StructureSection load='7stg' size='340' side='right'caption='[[7stg]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7stg]] is a 32 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Pongo_pygmaeus Pongo pygmaeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7STG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7STG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7stg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7stg OCA], [https://pdbe.org/7stg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7stg RCSB], [https://www.ebi.ac.uk/pdbsum/7stg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7stg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RADX_HUMAN RADX_HUMAN] Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability (PubMed:28735897). Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks (PubMed:28735897).<ref>PMID:28735897</ref> [https://www.uniprot.org/uniprot/A0A678ZGP6_HUMAN A0A678ZGP6_HUMAN] [https://www.uniprot.org/uniprot/B2MG_PONPY B2MG_PONPY] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Pongo pygmaeus]]
[[Category: Finton KAK]]
[[Category: Rupert PB]]