View source for 7sul


==Crystal structure of the WD-repeat domain of human SEC31A==
<StructureSection load='7sul' size='340' side='right'caption='[[7sul]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7sul]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SUL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sul OCA], [https://pdbe.org/7sul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sul RCSB], [https://www.ebi.ac.uk/pdbsum/7sul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sul ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SC31A_HUMAN SC31A_HUMAN] A chromosomal aberration involving SEC31A is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;4)(p23;q21) with ALK.
== Function ==
[https://www.uniprot.org/uniprot/SC31A_HUMAN SC31A_HUMAN] Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Dong A]]
[[Category: Edwards AM]]
[[Category: Halabelian L]]
[[Category: Hutchinson A]]
[[Category: Loppnau P]]
[[Category: Seitova A]]
[[Category: Zeng H]]