View source for 7szl


==Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1R10 (IL-1RAPL2)==
<StructureSection load='7szl' size='340' side='right'caption='[[7szl]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7szl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SZL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7szl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7szl OCA], [https://pdbe.org/7szl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7szl RCSB], [https://www.ebi.ac.uk/pdbsum/7szl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7szl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IRPL2_HUMAN IRPL2_HUMAN] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Toll/interleukin-1 receptor (TIR) domains are key innate immune signaling modules. Here, we present the crystal structure of the TIR domain of human Interleukin-1 receptor 10 (IL-1R10), also called IL-1RAPL2. It is similar to that of IL-1R9 (IL-1RAPL1) but shows significant structural differences to those from Toll-like receptors (TLRs) and the adaptor proteins MAL and MyD88. Interactions of TIR domains in their respective crystals and the higher-order assemblies (MAL and MyD88) reveal the presence of a common 'BCD surface', suggesting its functional significance. We also show that the TIR domains of IL-1R10 and IL-1R9 lack NADase activity, consistent with their structures. Our study provides a foundation for unraveling the functions of IL-1R9 and IL-1R10.

Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of IL-1R10 provides structural insights into TIR domain signaling.,Nimma S, Gu W, Manik MK, Ve T, Nanson JD, Kobe B FEBS Lett. 2022 Jan 17. doi: 10.1002/1873-3468.14288. PMID:35038778<ref>PMID:35038778</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7szl" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gu W]]
[[Category: Kobe B]]
[[Category: Manik MK]]
[[Category: Nanson JD]]
[[Category: Nimma S]]
[[Category: Ve T]]