View source for 7t26


==Structure of phage FBB1 anti-CBASS nuclease Acb1 in apo state==
<StructureSection load='7t26' size='340' side='right'caption='[[7t26]], [[Resolution|resolution]] 1.14&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7t26]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Erwinia_phage_FBB1 Erwinia phage FBB1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T26 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.14&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t26 OCA], [https://pdbe.org/7t26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t26 RCSB], [https://www.ebi.ac.uk/pdbsum/7t26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t26 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ACB1_BPFBB ACB1_BPFBB] Counteracts the host CBASS antiviral defense system. Phosphodiesterase that enables metal-independent hydrolysis of the host cyclic di- and trinucleotide CBASS signals such as 3'3'-cGAMP, 3'3'cUA, and 3'3'3'-cAAA (PubMed:35395152). Does not cleave cGG or cA4 (By similarity). Besides evasion of the CBASS system, might also enable evasion of the type III CRISPR systems that use cA3 signals (By similarity).[UniProtKB:P04533]<ref>PMID:35395152</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Erwinia phage FBB1]]
[[Category: Large Structures]]
[[Category: Hobbs SJ]]
[[Category: Kranzusch PJ]]
[[Category: Lu A]]
[[Category: Morehouse BR]]
[[Category: Schnabel J]]
[[Category: Sorek R]]
[[Category: Wein T]]