View source for 7t81


==Model of Munc13-1 C1-C2B-MUN-C2C 2D crystal between lipid bilayers.==
<StructureSection load='7t81' size='340' side='right'caption='[[7t81]], [[Resolution|resolution]] 10.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7t81]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T81 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t81 OCA], [https://pdbe.org/7t81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t81 RCSB], [https://www.ebi.ac.uk/pdbsum/7t81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t81 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UN13A_RAT UN13A_RAT] Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Also involved in secretory granule priming in insulin secretion.<ref>PMID:9697857</ref> <ref>PMID:11343654</ref> <ref>PMID:11792326</ref> [https://www.uniprot.org/uniprot/UN13A_MOUSE UN13A_MOUSE] Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (PubMed:23229896). Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (By similarity).[UniProtKB:Q62768][UniProtKB:Q9UPW8]<ref>PMID:10440375</ref> <ref>PMID:12070347</ref> <ref>PMID:15988013</ref> <ref>PMID:16644700</ref> <ref>PMID:16697276</ref> <ref>PMID:17267576</ref> <ref>PMID:17639022</ref> <ref>PMID:23229896</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Grushin K]]
[[Category: Sindelar CV]]