View source for 7tdr


==Labrum-interacting protein from saliva LIPS-2 (34K-2) from Aedes albopictus, selenomethionine derivative==
<StructureSection load='7tdr' size='340' side='right'caption='[[7tdr]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7tdr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aedes_albopictus Aedes albopictus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TDR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TDR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tdr OCA], [https://pdbe.org/7tdr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tdr RCSB], [https://www.ebi.ac.uk/pdbsum/7tdr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tdr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/34K2_AEDAL 34K2_AEDAL] Salivary protein that promotes mosquito blood feeding on the vertebrate host by inducing morphological changes in the mosquito labrum (PubMed:35835123). Interacts with the mosquito labrum end tip and triggers salivation and probing (PubMed:35835123). Modulates enzymatic activities of human tryptase and chymase (PubMed:35746853).<ref>PMID:35746853</ref> <ref>PMID:35835123</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The mosquito proboscis is an efficient microelectromechanical system, which allows the insect to feed on vertebrate blood quickly and painlessly. Its efficiency is further enhanced by the insect saliva, although through unclear mechanisms. Here, we describe the initial trigger of an unprecedented feedback signaling pathway in Aedes mosquitoes affecting feeding behavior. We identified LIPS proteins in the saliva of Aedes mosquitoes that promote feeding in the vertebrate skin. LIPS show a new all-helical protein fold constituted by two domains. The N-terminal domain interacts with a cuticular protein (Cp19) located at the tip of the mosquito labrum. Upon interaction, the morphology of the labral cuticle changes, and this modification is most likely sensed by proprioceptive neurons. Our study identifies an additional role of mosquito saliva and underlines that the external cuticle is a possible site of key molecular interactions affecting the insect biology and its vector competence.

A salivary factor binds a cuticular protein and modulates biting by inducing morphological changes in the mosquito labrum.,Arnoldi I, Mancini G, Fumagalli M, Gastaldi D, D'Andrea L, Bandi C, Di Venere M, Iadarola P, Forneris F, Gabrieli P Curr Biol. 2022 Aug 22;32(16):3493-3504.e11. doi: 10.1016/j.cub.2022.06.049. Epub , 2022 Jul 13. PMID:35835123<ref>PMID:35835123</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7tdr" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Aedes albopictus]]
[[Category: Large Structures]]
[[Category: Forneris F]]
[[Category: Gabrieli P]]