View source for 7tlr


==Structure of Atopobium parvulum SufS A34Y mutant==
<StructureSection load='7tlr' size='340' side='right'caption='[[7tlr]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7tlr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lancefieldella_parvula Lancefieldella parvula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TLR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tlr OCA], [https://pdbe.org/7tlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tlr RCSB], [https://www.ebi.ac.uk/pdbsum/7tlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tlr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/C8W9P2_LANP1 C8W9P2_LANP1] Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.[RuleBase:RU004506]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Crohn's disease (CD) is characterized by the chronic inflammation of the gastrointestinal tract. A dysbiotic microbiome and a defective immune system are linked to CD, where hydrogen sulfide (H2 S) microbial producers positively correlate with the severity of the disease. Atopobium parvulum is a key H2 S producer from the microbiome of CD patients. In this study, the biochemical characterization of two Atopobium parvulum cysteine desulfurases, ApSufS and ApCsdB, shows that the enzymes are allosterically regulated. Structural analyses reveal that ApSufS forms a dimer with conserved characteristics observed in type II cysteine desulfurases. Four residues surrounding the active site are essential to catalyse cysteine desulfurylation, and a segment of short-chain residues grant access for substrate binding. A better understanding of ApSufS will help future avenues for CD treatment.

Structural analysis of Atopobium parvulum SufS cysteine desulfurase linked to Crohn's disease.,Karunakaran G, Yang Y, Tremblay V, Ning Z, Martin J, Belaouad A, Figeys D, Brunzelle JS, Giguere PM, Stintzi A, Couture JF FEBS Lett. 2022 Feb 4. doi: 10.1002/1873-3468.14295. PMID:35122247<ref>PMID:35122247</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7tlr" style="background-color:#fffaf0;"></div>

==See Also==
*[[Cysteine desulfurase 3D structures|Cysteine desulfurase 3D structures]]
*[[Selenocysteine lyase|Selenocysteine lyase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Lancefieldella parvula]]
[[Category: Large Structures]]
[[Category: Couture JF]]
[[Category: Karunakaran G]]