View source for 7trs


==Human M4 muscarinic acetylcholine receptor complex with Gi1 and the endogenous agonist acetylcholine==
<StructureSection load='7trs' size='340' side='right'caption='[[7trs]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7trs]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TRS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACH:ACETYLCHOLINE'>ACH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7trs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7trs OCA], [https://pdbe.org/7trs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7trs RCSB], [https://www.ebi.ac.uk/pdbsum/7trs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7trs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ACM4_HUMAN ACM4_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.

==See Also==
*[[Muscarinic acetylcholine receptor|Muscarinic acetylcholine receptor]]
*[[Transducin 3D structures|Transducin 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Belousoff MJ]]
[[Category: Danev R]]
[[Category: Glukhova A]]
[[Category: Mobbs JI]]
[[Category: Sexton PM]]
[[Category: Thal DM]]
[[Category: Vuckovic Z]]