View source for 7tuk


==Small hepatitis B virus surface protein without cytosolic and antigenic loops==
<StructureSection load='7tuk' size='340' side='right'caption='[[7tuk]], [[Resolution|resolution]] 6.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7tuk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_B_virus_genotype_E Hepatitis B virus genotype E]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TUK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tuk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tuk OCA], [https://pdbe.org/7tuk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tuk RCSB], [https://www.ebi.ac.uk/pdbsum/7tuk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tuk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q460Z9_HBV Q460Z9_HBV] The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.[HAMAP-Rule:MF_04075]  The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.[HAMAP-Rule:MF_04075]
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</StructureSection>
[[Category: Hepatitis B virus genotype E]]
[[Category: Large Structures]]
[[Category: Liu H]]
[[Category: Wang JCY]]