View source for 7u45


==[L344] Self-assembling tensegrity triangle with three turns, four turns and four turns of DNA per axis by extension and linker addition with P1 symmetry==
<StructureSection load='7u45' size='340' side='right'caption='[[7u45]], [[Resolution|resolution]] 8.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7u45]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U45 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 8.05&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u45 OCA], [https://pdbe.org/7u45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u45 RCSB], [https://www.ebi.ac.uk/pdbsum/7u45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u45 ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
The DNA tensegrity triangle is known to reliably self-assemble into a 3D rhombohedral crystalline lattice via sticky-end cohesion. Here, we expand the library of accessible motifs through (1) covalent extensions of inter-triangle regions and (2) sticky-end coordinated linkages of adjacent triangles with double helical segments using both geometrically symmetric and asymmetric configurations. We report the molecular structures of eighteen self-assembled architectures at resolutions of 3.32-9.32 A; the observed cell dimensions, cavity sizes, and cross-sectional areas agree with theoretical expectations. These data demonstrate that fine control over triclinic and rhombohedral crystal parameters and the customizability of more complex 3D DNA lattices are attainable via rational design. We anticipate that augmented DNA architectures may be fine-tuned for the self-assembly of designer nano-cages, guest-host complexes, and proscriptive 3D nanomaterials, as originally envisioned. Finally, designer asymmetric crystalline building blocks can be seen as a first step toward controlling and encoding information in three dimensions. This article is protected by copyright. All rights reserved.

Augmented DNA Nano-Architectures: A Structural Library of 3D Self-Assembling Tensegrity Triangle Variants.,Woloszyn K, Vecchioni S, Ohayon YP, Lu B, Ma Y, Huang Q, Zhu E, Chernovolenko D, Markus T, Jonoska N, Mao C, Seeman NC, Sha R Adv Mater. 2022 Sep 13:e2206876. doi: 10.1002/adma.202206876. PMID:36100349<ref>PMID:36100349</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Ohayon YP]]
[[Category: Seeman NC]]
[[Category: Sha R]]
[[Category: Vecchioni S]]
[[Category: Woloszyn K]]