View source for 7uhg


==Human L-type voltage-gated calcium channel Cav1.3 at 3.0 Angstrom resolution==
<StructureSection load='7uhg' size='340' side='right'caption='[[7uhg]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7uhg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UHG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uhg OCA], [https://pdbe.org/7uhg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uhg RCSB], [https://www.ebi.ac.uk/pdbsum/7uhg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uhg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CACB3_HUMAN CACB3_HUMAN] Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).[UniProtKB:P54287][UniProtKB:Q9MZL3]<ref>PMID:8119293</ref> 

==See Also==
*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gao S]]
[[Category: Yan N]]
[[Category: Yao X]]