View source for 7ulq


==Recombinant Hannalgesin==
<StructureSection load='7ulq' size='340' side='right'caption='[[7ulq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ulq]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ULQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ULQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ulq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ulq OCA], [https://pdbe.org/7ulq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ulq RCSB], [https://www.ebi.ac.uk/pdbsum/7ulq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ulq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/3L255_OPHHA 3L255_OPHHA] Binds to muscular and neuronal nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission (PubMed:35341214). Pseudo-irreversibly inhibits twitches in chick biventer cervicis nerve-muscle preparations in a concentration-dependent manner (PubMed:35341214).<ref>PMID:35341214</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Ophiophagus hannah]]
[[Category: Chen L]]
[[Category: Lei X]]
[[Category: Xu J]]