View source for 7uqc


==phospho-GlialCAM peptide AA370-389 with Fab MS39p2w174==
<StructureSection load='7uqc' size='340' side='right'caption='[[7uqc]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7uqc]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UQC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uqc OCA], [https://pdbe.org/7uqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uqc RCSB], [https://www.ebi.ac.uk/pdbsum/7uqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uqc ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/HECAM_HUMAN HECAM_HUMAN] Megalencephalic leukoencephalopathy with subcortical cysts;Macrocephaly-intellectual disability-autism syndrome. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/HECAM_HUMAN HECAM_HUMAN] Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (PubMed:15885354, PubMed:15917256). In glia, associates and targets CLCN2 at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux involved in neuron excitability (PubMed:22405205).<ref>PMID:15885354</ref> <ref>PMID:15917256</ref> <ref>PMID:22405205</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fernandez D]]
[[Category: Lanz TV]]
[[Category: Robinson WH]]