View source for 7usw


==Structure of Expanded C. elegans TMC-1 complex==
<StructureSection load='7usw' size='340' side='right'caption='[[7usw]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7usw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7USW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7USW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene>, <scene name='pdbligand=ZFC:undecan-1-ol'>ZFC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7usw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7usw OCA], [https://pdbe.org/7usw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7usw RCSB], [https://www.ebi.ac.uk/pdbsum/7usw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7usw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TMC1_CAEEL TMC1_CAEEL] Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex (PubMed:36224384). The MET complex is composed of symmetric dimeric MET channels, each channel comprising two copies of pore-forming ion-conducting transmembrane TMC subunits and auxiliary proteins including the transmembrane inner ear protein/tmie, the calcium-binding protein/calm-1 and arrestin domain protein arrd-6 (PubMed:36224384). Sodium ions are the most permeable, whereas calcium and potassium have lower indices (PubMed:23364694). Sodium-sensor ion channel that acts specifically in salt taste chemosensation. Required for salt-evoked neuronal activity and behavioral avoidance of high concentrations of NaCl.<ref>PMID:23364694</ref> <ref>PMID:36224384</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Large Structures]]
[[Category: Clark S]]
[[Category: Gouaux E]]
[[Category: Jeong H]]