View source for 7vby


==Tom core complex with Tom20 and Tom22 subunits.==
<StructureSection load='7vby' size='340' side='right'caption='[[7vby]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7vby]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VBY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.54&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=UND:UNDECANE'>UND</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vby OCA], [https://pdbe.org/7vby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vby RCSB], [https://www.ebi.ac.uk/pdbsum/7vby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vby ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TOM40_HUMAN TOM40_HUMAN] Early-onset autosomal dominant Alzheimer disease. 
== Function ==
[https://www.uniprot.org/uniprot/TOM20_HUMAN TOM20_HUMAN] Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).[https://www.uniprot.org/uniprot/TOM40_HUMAN TOM40_HUMAN] Channel-forming protein essential for import of protein precursors into mitochondria (PubMed:15644312, PubMed:31206022). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria (PubMed:31206022).<ref>PMID:15644312</ref> <ref>PMID:31206022</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Liu DS]]
[[Category: Sui SF]]