View source for 7vkk


==Crystal structure of D. melanogaster SAMTOR V66W/E67P mutant==
<StructureSection load='7vkk' size='340' side='right'caption='[[7vkk]], [[Resolution|resolution]] 3.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7vkk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VKK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.55&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vkk OCA], [https://pdbe.org/7vkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vkk RCSB], [https://www.ebi.ac.uk/pdbsum/7vkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vkk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SAMTR_DROME SAMTR_DROME] S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling (PubMed:29123071). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1 (PubMed:29123071). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.[HAMAP-Rule:MF_03044]<ref>PMID:29123071</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Ding J]]
[[Category: Zhang T]]