View source for 7w80


==Crystal Structure of the Heterodimeric HIF-2 in Complex with Antagonist Belzutifan==
<StructureSection load='7w80' size='340' side='right'caption='[[7w80]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7w80]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W80 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.754&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=72Q:3-{[(1S,2S,3R)-2,3-DIFLUORO-1-HYDROXY-7-(METHYLSULFONYL)-2,3-DIHYDRO-1H-INDEN-4-YL]OXY}-5-FLUOROBENZONITRILE'>72Q</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w80 OCA], [https://pdbe.org/7w80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w80 RCSB], [https://www.ebi.ac.uk/pdbsum/7w80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w80 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ARNT_MOUSE ARNT_MOUSE] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity).

==See Also==
*[[3D structures of hypoxia-inducible factor|3D structures of hypoxia-inducible factor]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Diao X]]
[[Category: Ren X]]
[[Category: Wu D]]
[[Category: Zhuang J]]