View source for 7wih


==Cryo-EM structure of LY2794193-bound mGlu3==
<StructureSection load='7wih' size='340' side='right'caption='[[7wih]], [[Resolution|resolution]] 3.68&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7wih]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WIH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CWY:(1S,2S,4S,5R,6S)-2-amino-4-[(3-methoxybenzene-1-carbonyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic+acid'>CWY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wih OCA], [https://pdbe.org/7wih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wih RCSB], [https://www.ebi.ac.uk/pdbsum/7wih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wih ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/GRM3_HUMAN GRM3_HUMAN]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.<ref>PMID:8840013</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fang W]]
[[Category: Lin L]]
[[Category: Ling SL]]
[[Category: Liu JF]]
[[Category: Liu P]]
[[Category: Pan S]]
[[Category: Pin JP]]
[[Category: Rondard P]]
[[Category: Sun WJ]]
[[Category: Tian CL]]
[[Category: Wang XM]]
[[Category: Xu CJ]]
[[Category: Yang F]]
[[Category: Zhou YX]]