View source for 7wiv


==Cryo-EM structure of Mycobacterium tuberculosis irtAB in complex with an AMP-PNP==
<StructureSection load='7wiv' size='340' side='right'caption='[[7wiv]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7wiv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WIV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.88&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wiv OCA], [https://pdbe.org/7wiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wiv RCSB], [https://www.ebi.ac.uk/pdbsum/7wiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wiv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IRTA_MYCTU IRTA_MYCTU] Part of the ABC transporter complex IrtAB involved in the import of iron-bound mycobactin (Fe-MBT) and carboxymycobactin (Fe-cMBT) (PubMed:16385031, PubMed:19948799) (By similarity). Mycobactins are then reduced by the siderophore interaction domain to facilitate iron release in the bacterial cell (By similarity). Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity). Required for replication in human macrophages and in mouse lungs (PubMed:16385031).[UniProtKB:G7CBF5]<ref>PMID:16385031</ref> <ref>PMID:19948799</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Rao Z]]
[[Category: Sun S]]
[[Category: Yang H]]
[[Category: Zhang B]]