View source for 7wji


==Architecture of the human NALCN channelosome==
<StructureSection load='7wji' size='340' side='right'caption='[[7wji]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7wji]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WJI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wji OCA], [https://pdbe.org/7wji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wji RCSB], [https://www.ebi.ac.uk/pdbsum/7wji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wji ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/UNC80_HUMAN UNC80_HUMAN] Hypotonia-speech impairment-severe cognitive delay syndrome. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/UNC80_HUMAN UNC80_HUMAN] Auxiliary subunit of the NALCN sodium channel complex, a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (By similarity). Activated by neuropeptides substance P, neurotensin, and extracellular Ca(2+) that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular Ca(2+) (By similarity).[UniProtKB:Q8BLN6]

==See Also==
*[[Calmodulin 3D structures|Calmodulin 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Liu H]]
[[Category: Wu JP]]
[[Category: Yan Z]]
[[Category: Zhao Q]]
[[Category: Zhou L]]