View source for 7wq4


==Galanin-bound galanin receptor 2 in complex with Gq==
<StructureSection load='7wq4' size='340' side='right'caption='[[7wq4]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7wq4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Rattus Rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WQ4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wq4 OCA], [https://pdbe.org/7wq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wq4 RCSB], [https://www.ebi.ac.uk/pdbsum/7wq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wq4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GALR2_HUMAN GALR2_HUMAN] Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).<ref>PMID:24517231</ref> <ref>PMID:25691535</ref> <ref>PMID:9480833</ref> <ref>PMID:9685625</ref> <ref>PMID:9832121</ref> <ref>PMID:9880084</ref> 

==See Also==
*[[Transducin 3D structures|Transducin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Homo sapiens]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Rattus]]
[[Category: Duan J]]
[[Category: Jiang Y]]
[[Category: Shen DD]]
[[Category: Xu HE]]
[[Category: Zhang Y]]