View source for 7wtu


==Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A1 (without CK1)==
<StructureSection load='7wtu' size='340' side='right'caption='[[7wtu]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7wtu]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WTU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G7M:N7-METHYL-GUANOSINE-5-MONOPHOSPHATE'>G7M</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wtu OCA], [https://pdbe.org/7wtu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wtu RCSB], [https://www.ebi.ac.uk/pdbsum/7wtu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wtu ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/RS17_HUMAN RS17_HUMAN] Blackfan-Diamond disease. Diamond-Blackfan anemia 4 (DBA4) [MIM:[https://omim.org/entry/612527 612527]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of developing leukemia. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:17647292</ref> <ref>PMID:19061985</ref> 
== Function ==
[https://www.uniprot.org/uniprot/RS17_HUMAN RS17_HUMAN] 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ameismeier M]]
[[Category: Beckmann R]]
[[Category: Berninghausen O]]
[[Category: Cheng J]]
[[Category: Hurt E]]
[[Category: Lau B]]
[[Category: Thoms M]]