View source for 7wvx


==Cryo-EM structure of the human formyl peptide receptor 2 in complex with fhumanin and Gi2==
<StructureSection load='7wvx' size='340' side='right'caption='[[7wvx]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7wvx]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WVX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wvx OCA], [https://pdbe.org/7wvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wvx RCSB], [https://www.ebi.ac.uk/pdbsum/7wvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wvx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HUNIN_HUMAN HUNIN_HUMAN] Plays a role as a neuroprotective factor. Protects against death induced by multiple different familial Alzheimer disease genes and beta amyloid proteins in Alzheimer disease. Suppresses apoptosis by binding to BAX and preventing the translocation of BAX from the cytosol to mitochondria. Binds to IGFBP3 and specifically blocks IGFBP3-induced cell death Induces chemotaxis of mononuclear phagocytes via FPR2. Reduces the aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and acts by competitively inhibiting the access of FPRL1 to APP.<ref>PMID:11371646</ref> <ref>PMID:14561895</ref> <ref>PMID:11717357</ref> <ref>PMID:12732850</ref> <ref>PMID:15153530</ref> 
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== Publication Abstract from PubMed ==
Formyl peptide receptor 2 (FPR2) has been shown to mediate the cytotoxic effects of the beta amyloid peptide Abeta(42) and serves as a receptor for humanin, a peptide that protects neuronal cells from damage by Abeta(42), implying its involvement in the pathogenesis of Alzheimer's disease (AD). However, the interaction pattern between FPR2 and Abeta(42) or humanin remains unknown. Here we report the structures of FPR2 bound to G(i) and Abeta(42) or N-formyl humanin (fHN). Combined with functional data, the structures reveal two critical regions that govern recognition and activity of Abeta(42) and fHN, including a polar binding cavity within the receptor helical bundle and a hydrophobic binding groove in the extracellular region. In addition, the structures of FPR2 and FPR1 in complex with different formyl peptides were determined, providing insights into ligand recognition and selectivity of the FPR family. These findings uncover key factors that define the functionality of FPR2 in AD and other inflammatory diseases and would enable drug development.

Structural basis of FPR2 in recognition of Abeta(42) and neuroprotection by humanin.,Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, Ma L, Chu X, Yi C, Zhao Q, Wu B Nat Commun. 2022 Apr 1;13(1):1775. doi: 10.1038/s41467-022-29361-x. PMID:35365641<ref>PMID:35365641</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 7wvx" style="background-color:#fffaf0;"></div>

==See Also==
*[[Transducin 3D structures|Transducin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Han S]]
[[Category: Lin X]]
[[Category: Wu B]]
[[Category: Zhao Q]]
[[Category: Zhu Y]]
[[Category: Zong X]]