View source for 7wwp


==Crystal structure of human Npl4==
<StructureSection load='7wwp' size='340' side='right'caption='[[7wwp]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7wwp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WWP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wwp OCA], [https://pdbe.org/7wwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wwp RCSB], [https://www.ebi.ac.uk/pdbsum/7wwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wwp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NPL4_HUMAN NPL4_HUMAN] The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729).[UniProtKB:Q9ES54]<ref>PMID:26471729</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Han BW]]
[[Category: Kang W]]
[[Category: Kim DH]]
[[Category: Kim HS]]
[[Category: Ko KS]]
[[Category: Le LTM]]
[[Category: Lee HT]]
[[Category: Nguyen TQ]]
[[Category: Nguyen YTK]]
[[Category: Yang JK]]