View source for 7x43


==Crystal structure of chlorotoxin mutant - M1R==
<StructureSection load='7x43' size='340' side='right'caption='[[7x43]], [[Resolution|resolution]] 1.04&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7x43]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X43 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.04&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x43 OCA], [https://pdbe.org/7x43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x43 RCSB], [https://www.ebi.ac.uk/pdbsum/7x43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x43 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CTXL_LEIQU CTXL_LEIQU] This toxin binds to the surface of glioma cells, and inhibits their proliferation without having effects on normal brain cells. In this context, this toxin has been described as a chloride channel inhibitor (probably ClC-3/CLCN3) by causing its internalization via caveolae (PubMed:16520829). It has also been described to selectively interact with MMP2 (in complex with MT1-MMP (MMP14) and TIMP2), to inhibit its enzymatic activity and to decrease its presence at the cell surface (PubMed:12454020).<ref>PMID:12454020</ref> <ref>PMID:16520829</ref> <ref>PMID:8383429</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Leiurus quinquestriatus quinquestriatus]]
[[Category: Chang YT]]
[[Category: Chuang WJ]]