View source for 7xgb


==Crystal structure of the ctcP from Streptomyces aureofaciens==
<StructureSection load='7xgb' size='340' side='right'caption='[[7xgb]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7xgb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Kitasatospora_aureofaciens Kitasatospora aureofaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XGB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xgb OCA], [https://pdbe.org/7xgb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xgb RCSB], [https://www.ebi.ac.uk/pdbsum/7xgb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xgb ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/CTCP_KITAU CTCP_KITAU]] Involved in the biosynthesis of chlorotetracycline (CTC), an important member from antibiotics tetracycline (TC) family, which inhibits protein synthesis in bacteria and is widely involved in clinical therapy, animal feeds and aquaculture. Utilizes FADH(2) supplied by the flavin reductase CtcQ, to catalyze the chlorination of tetracycline (TC) at C7 position, leading to the production of 7-chlorotetracycline. The enzyme forms a lysine chloramine intermediate on an internal lysine residue before transferring the chlorine to the substrate. It is stereo-selective for the 4S (natural) isomer of tetracycline.<ref>PMID:23800859</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Kitasatospora aureofaciens]]
[[Category: Large Structures]]
[[Category: Yin L]]