View source for 7xhv


==Crystal Structure of the NPAS4-ARNT heterodimer in complex with DNA==
<StructureSection load='7xhv' size='340' side='right'caption='[[7xhv]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7xhv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XHV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.996&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xhv OCA], [https://pdbe.org/7xhv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xhv RCSB], [https://www.ebi.ac.uk/pdbsum/7xhv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xhv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ARNT_MOUSE ARNT_MOUSE] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity).

==See Also==
*[[3D structures of hypoxia-inducible factor|3D structures of hypoxia-inducible factor]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Jing LQ]]
[[Category: Li FW]]
[[Category: Sun XN]]
[[Category: Wu DL]]