View source for 7xlm


==Human diastrophic dysplasia sulfate transporter SLC26A2==
<StructureSection load='7xlm' size='340' side='right'caption='[[7xlm]], [[Resolution|resolution]] 3.73&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7xlm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XLM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.73&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xlm OCA], [https://pdbe.org/7xlm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xlm RCSB], [https://www.ebi.ac.uk/pdbsum/7xlm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xlm ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/S26A2_HUMAN S26A2_HUMAN] Atelosteogenesis type II;Diastrophic dysplasia;Achondrogenesis type 1B;Multiple epiphyseal dysplasia type 4. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/S26A2_HUMAN S26A2_HUMAN] Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development (PubMed:11448940, PubMed:15294877, PubMed:20219950, PubMed:7923357). Mediates electroneutral anion exchange of sulfate ions for oxalate ions and of sulfate and oxalate ions for chloride ions (PubMed:20219950). Mediates exchange of sulfate and oxalate ions for hydroxyl ions and of chloride ions for bromide, iodide and nitrate ions (By similarity). The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange (By similarity). Essential for chondrocyte proliferation, differentiation and cell size expansion (By similarity).[UniProtKB:Q62273]<ref>PMID:11448940</ref> <ref>PMID:15294877</ref> <ref>PMID:20219950</ref> <ref>PMID:7923357</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chi XM]]
[[Category: Zhou Q]]