View source for 7xva


==Crystal structure of the Human TR4 Ligand Binding Domain in complex with the JAZF1 corepressor fragment==
<StructureSection load='7xva' size='340' side='right'caption='[[7xva]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7xva]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XVA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.856&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xva OCA], [https://pdbe.org/7xva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xva RCSB], [https://www.ebi.ac.uk/pdbsum/7xva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xva ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NR2C2_HUMAN NR2C2_HUMAN] Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.<ref>PMID:7779113</ref> <ref>PMID:9556573</ref> <ref>PMID:10347174</ref> <ref>PMID:10644740</ref> <ref>PMID:17974920</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen Z]]
[[Category: Liu Y]]