View source for 7xyz


==TRIM E3 ubiquitin ligase==
<StructureSection load='7xyz' size='340' side='right'caption='[[7xyz]], [[Resolution|resolution]] 4.62&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7xyz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XYZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.62&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xyz OCA], [https://pdbe.org/7xyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xyz RCSB], [https://www.ebi.ac.uk/pdbsum/7xyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xyz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRI72_MOUSE TRI72_MOUSE] Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.<ref>PMID:19029292</ref> <ref>PMID:19043407</ref> <ref>PMID:19202355</ref> <ref>PMID:19380584</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Park SH]]
[[Category: Song HK]]