View source for 7y54


==Crystal structure of sDscam Ig1 domain, isoform alpha1==
<StructureSection load='7y54' size='340' side='right'caption='[[7y54]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7y54]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chelicerata Chelicerata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y54 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.787&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y54 OCA], [https://pdbe.org/7y54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y54 RCSB], [https://www.ebi.ac.uk/pdbsum/7y54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y54 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
To create a functional neural circuit, neurons develop a molecular identity to discriminate self from non-self. The invertebrate Dscam family and vertebrate Pcdh family are implicated in determining synaptic specificity. Recently identified in Chelicerata, a shortened Dscam (sDscam) has been shown to resemble the isoform-generating characters of both Dscam and Pcdh and represent an evolutionary transition. Here we presented the molecular details of sDscam self-recognition via both trans and cis interactions using X-ray crystallographic data and functional assays. Based on our results, we proposed a molecular zipper model for the assemblies of sDscam to mediate cell-cell recognition. In this model, sDscam utilized FNIII domain to form side-by-side interactions with neighboring molecules in the same cell while established hand-in-hand interactions via Ig1 domain with molecules from another cell around. Together, our study provided a framework for understanding the assembly, recognition, and evolution of sDscam.

Structural basis for the self-recognition of sDSCAM in Chelicerata.,Cheng J, Yu Y, Wang X, Zheng X, Liu T, Hu D, Jin Y, Lai Y, Fu TM, Chen Q Nat Commun. 2023 May 2;14(1):2522. doi: 10.1038/s41467-023-38205-1. PMID:37130844<ref>PMID:37130844</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7y54" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Chelicerata]]
[[Category: Large Structures]]
[[Category: Chen Q]]
[[Category: Cheng J]]
[[Category: Yu Y]]