View source for 7yan


==UDP-glucuronosyltransferase2B17 C-terminal domain==
<StructureSection load='7yan' size='340' side='right'caption='[[7yan]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7yan]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YAN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yan OCA], [https://pdbe.org/7yan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yan RCSB], [https://www.ebi.ac.uk/pdbsum/7yan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yan ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UDB17_HUMAN UDB17_HUMAN] UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:8798464, PubMed:16595710, PubMed:18719240, PubMed:19022937, PubMed:23288867). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol) (PubMed:8798464, PubMed:16595710, PubMed:18719240, PubMed:19022937, PubMed:23288867).<ref>PMID:16595710</ref> <ref>PMID:18719240</ref> <ref>PMID:19022937</ref> <ref>PMID:23288867</ref> <ref>PMID:8798464</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Wang CY]]
[[Category: Zhang L]]