View source for 7ydg


==Crystal structure of human SARS2 catalytic domain with a disease related mutation==
<StructureSection load='7ydg' size='340' side='right'caption='[[7ydg]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ydg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YDG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ydg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ydg OCA], [https://pdbe.org/7ydg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ydg RCSB], [https://www.ebi.ac.uk/pdbsum/7ydg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ydg ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/SYSM_HUMAN SYSM_HUMAN] Hyperuricemia-pulmonary hypertension-renal failure-alkalosis syndrome. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/SYSM_HUMAN SYSM_HUMAN] Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).[UniProtKB:Q9N0F3]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fang P]]
[[Category: Li P]]
[[Category: Wu S]]
[[Category: Zhou XL]]