View source for 7yfj


==Crystal structure of human WTAP==
<StructureSection load='7yfj' size='340' side='right'caption='[[7yfj]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7yfj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YFJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YFJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yfj OCA], [https://pdbe.org/7yfj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yfj RCSB], [https://www.ebi.ac.uk/pdbsum/7yfj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yfj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FL2D_HUMAN FL2D_HUMAN] Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).<ref>PMID:12444081</ref> <ref>PMID:17088532</ref> <ref>PMID:17095724</ref> <ref>PMID:24316715</ref> <ref>PMID:24407421</ref> <ref>PMID:24981863</ref> <ref>PMID:29507755</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Guan ZY]]
[[Category: Tang C]]
[[Category: Yan XH]]
[[Category: Yin P]]