View source for 7yke


==Crystal structure of chondroitin ABC lyase I in complex with chondroitin disaccharide 4,6-sulfate==
<StructureSection load='7yke' size='340' side='right'caption='[[7yke]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7yke]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Proteus_vulgaris Proteus vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YKE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8EX:2-acetamido-2-deoxy-4,6-di-O-sulfo-beta-D-galactopyranose'>8EX</scene>, <scene name='pdbligand=GCD:4,5-DEHYDRO-D-GLUCURONIC+ACID'>GCD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yke OCA], [https://pdbe.org/7yke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yke RCSB], [https://www.ebi.ac.uk/pdbsum/7yke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yke ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CABC1_PROVU CABC1_PROVU] Endolytic, broad-specificity glycosaminoglycan lyase, which degrades the polysaccharides chondroitin, chondroitin-4-sulfate, chondroitin-6-sulfate, dermatan sulfate and to a lesser extent hyaluronan, by beta-elimination of 1,4-hexosaminidic bond to unsaturated tetrasaccharides and disaccharides. Is not active against keratan sulfate, heparan sulfate, and heparin. Is able to promote functional recovery in the injured central nervous system (CNS), via its role in the disruption of the normal organization of the extracellular matrix (ECM).<ref>PMID:15691229</ref> <ref>PMID:17572406</ref> <ref>PMID:9083041</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Proteus vulgaris]]
[[Category: Eguchi T]]
[[Category: Miyanaga A]]
[[Category: Takashima M]]
[[Category: Watanabe I]]