View source for 7yl2


==Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor Y07004==
<StructureSection load='7yl2' size='340' side='right'caption='[[7yl2]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7yl2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YL2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=JCO:N-(1-ethyl-2-oxidanylidene-3H-indol-5-yl)cyclohexanesulfonamide'>JCO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yl2 OCA], [https://pdbe.org/7yl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yl2 RCSB], [https://www.ebi.ac.uk/pdbsum/7yl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yl2 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> 
== Function ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen Z]]
[[Category: Dong R]]
[[Category: Huang Y]]
[[Category: Li J]]
[[Category: Wei A]]
[[Category: Wu X]]
[[Category: Xu H]]
[[Category: Xu Y]]
[[Category: Zhang C]]
[[Category: Zhang Y]]