View source for 7ypk


==Close-ring hexamer of the substrate-bound Lon protease with an S678A mutation==
<StructureSection load='7ypk' size='340' side='right'caption='[[7ypk]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ypk]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Meiothermus_taiwanensis Meiothermus taiwanensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YPK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YPK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ypk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ypk OCA], [https://pdbe.org/7ypk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ypk RCSB], [https://www.ebi.ac.uk/pdbsum/7ypk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ypk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A059VAZ3_9DEIN A0A059VAZ3_9DEIN] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.[HAMAP-Rule:MF_01973]
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Large Structures]]
[[Category: Meiothermus taiwanensis]]
[[Category: Chang CI]]
[[Category: Ho MR]]
[[Category: Hsieh KY]]
[[Category: Kuo CI]]
[[Category: Lee SH]]
[[Category: Li S]]
[[Category: Wang CH]]
[[Category: Zhang K]]