View source for 7yul


==Crystal structure of human BEND6 BEN domain in complex with DNA==
<StructureSection load='7yul' size='340' side='right'caption='[[7yul]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7yul]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YUL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOA:GLYCOLIC+ACID'>GOA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yul OCA], [https://pdbe.org/7yul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yul RCSB], [https://www.ebi.ac.uk/pdbsum/7yul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yul ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BEND6_HUMAN BEND6_HUMAN] Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis (PubMed:23571214).<ref>PMID:23571214</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Liu K]]
[[Category: Min JR]]
[[Category: Xiao YQ]]
[[Category: Zhang J]]