View source for 7yxd


==Crystal structure of WT AncGR2-LBD bound to dexamethasone and SHP coregulator fragment==
<StructureSection load='7yxd' size='340' side='right'caption='[[7yxd]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7yxd]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YXD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DEX:DEXAMETHASONE'>DEX</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yxd OCA], [https://pdbe.org/7yxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yxd RCSB], [https://www.ebi.ac.uk/pdbsum/7yxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yxd ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/NR0B2_HUMAN NR0B2_HUMAN] Defects in NR0B2 may be associated with obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:11136233</ref> 
== Function ==
[https://www.uniprot.org/uniprot/NR0B2_HUMAN NR0B2_HUMAN] Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.<ref>PMID:14752053</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Unidentified]]
[[Category: Estebanez-Perpina E]]
[[Category: Fuentes-Prior P]]
[[Category: Jimenez-Panizo A]]