View source for 7yxw


==Structure of the p22phox A200G mutant in complex with p47phox peptide==
<StructureSection load='7yxw' size='340' side='right'caption='[[7yxw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7yxw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YXW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yxw OCA], [https://pdbe.org/7yxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yxw RCSB], [https://www.ebi.ac.uk/pdbsum/7yxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yxw ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CY24A_HUMAN CY24A_HUMAN] Defects in CYBA are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-negative (ARCGD) [MIM:[https://omim.org/entry/233690 233690]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.<ref>PMID:2243141</ref> <ref>PMID:1415254</ref> <ref>PMID:1763037</ref> <ref>PMID:8168815</ref> <ref>PMID:7964505</ref> <ref>PMID:10910929</ref> <ref>PMID:10759707</ref> <ref>PMID:10914676</ref> <ref>PMID:18422995</ref> 
== Function ==
[https://www.uniprot.org/uniprot/CY24A_HUMAN CY24A_HUMAN] Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.<ref>PMID:15824103</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cukier CD]]
[[Category: Komjati B]]
[[Category: Szlavik Z]]
[[Category: Vuillard LM]]